The Effect of Chitosan and Chitosan Oligosaccharide on Serum Mineral and Vitamin Levels in Rats with Experimental Fluorosis

Fluorine toxicity occurs in different parts of the world. It is caused by increase fluorine level waters, especially due to dissolution volcanic rocks over time. Water with high flüorine content can be taken plant and animal irrigations, foods obtained from plants animals, or it directly drinking water.
 In this study, effects chitosan (CS) oligosaccharide (COS) on some serum trace minerals vitamin levels experimental fluorosis rats were investigated. Six groups formed as control, fluorosis, groups, healthy chitosanoligosaccharide groups. CS COS administered orally at a dose 250 mg/kg. At end ketamine anesthesia was heart cannulated. Trace (Cu, Zn, Mn, Fe, Se) vitamins (retinol, α-tocopherol, D3) analyzed. Cu, Se Mn found decreased F group compared control group. A significant Zn F+CS values group.
 Serum retinol α -tocopherol F, F+CS, F+COS conclusion, our findings showed that there decrease Se, α-tocopherol more effective than against mineral levels.